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### Network
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[[/pics/ycm_cell_cycle_scheme_20131011.png]]
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![](/pics/ycm_cell_cycle_scheme_20131011.png)
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We implemented this NW in python. Is running, pars arbitrary and not adjusted -> lot of flat-lines.
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... | ... | @@ -74,13 +74,13 @@ We implemented this NW in python. Is running, pars arbitrary and not adjusted -> |
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* Parameters adjusted -> protein concentrations still not correct, but stable oscillations.
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Far1-mechanism (separate view):
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[[/pics/ycm_cell_cycle_scheme_20140122_Far1.png]]
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![](/pics/ycm_cell_cycle_scheme_20140122_Far1.png)
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* We included two types of phosphorylations on Far1 that play a role in the mechanism:
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* T306: Stabilizing phosphorylation by Fus3
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* S86: Phosphorylation mediated by Cln2 leading to destruction of Far1
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The updated version of the Network including the new Far1-mechanism (see above) looks as follows:
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[[/pics/ycm_cell_cycle_scheme_20140124.png]]
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![](/pics/ycm_cell_cycle_scheme_20140124.png)
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#### Issues
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* Sic1 level deceases while cell is arrested
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... | ... | @@ -115,7 +115,7 @@ The updated version of the Network including the new Far1-mechanism (see above) |
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* For consistency, all species are now produced as well as degraded.
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* CDC module was split into a regulating module and the GEX_TRX/TRL modules to represent the different functions.
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* The current model structure looks like this:
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[[/pics/ycm_cell_cycle_scheme_20170925.png]]
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![](/pics/ycm_cell_cycle_scheme_20170925.png)
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## Other Cell Cycle Models
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**Barik et al. (2010) [20739927](http://www.ncbi.nlm.nih.gov/pubmed/20739927):**
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