Update CDC authored by Friedemann Uschner's avatar Friedemann Uschner
......@@ -59,7 +59,7 @@ Components excluded for now:
### Network
[[/pics/ycm_cell_cycle_scheme_20131011.png]]
![](/pics/ycm_cell_cycle_scheme_20131011.png)
We implemented this NW in python. Is running, pars arbitrary and not adjusted -> lot of flat-lines.
......@@ -74,13 +74,13 @@ We implemented this NW in python. Is running, pars arbitrary and not adjusted ->
* Parameters adjusted -> protein concentrations still not correct, but stable oscillations.
Far1-mechanism (separate view):
[[/pics/ycm_cell_cycle_scheme_20140122_Far1.png]]
![](/pics/ycm_cell_cycle_scheme_20140122_Far1.png)
* We included two types of phosphorylations on Far1 that play a role in the mechanism:
* T306: Stabilizing phosphorylation by Fus3
* S86: Phosphorylation mediated by Cln2 leading to destruction of Far1
The updated version of the Network including the new Far1-mechanism (see above) looks as follows:
[[/pics/ycm_cell_cycle_scheme_20140124.png]]
![](/pics/ycm_cell_cycle_scheme_20140124.png)
#### Issues
* Sic1 level deceases while cell is arrested
......@@ -115,7 +115,7 @@ The updated version of the Network including the new Far1-mechanism (see above)
* For consistency, all species are now produced as well as degraded.
* CDC module was split into a regulating module and the GEX_TRX/TRL modules to represent the different functions.
* The current model structure looks like this:
[[/pics/ycm_cell_cycle_scheme_20170925.png]]
![](/pics/ycm_cell_cycle_scheme_20170925.png)
## Other Cell Cycle Models
**Barik et al. (2010) [20739927](http://www.ncbi.nlm.nih.gov/pubmed/20739927):**
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