... | ... | @@ -74,13 +74,13 @@ We implemented this NW in python. Is running, pars arbitrary and not adjusted -> |
|
|
* Parameters adjusted -> protein concentrations still not correct, but stable oscillations.
|
|
|
|
|
|
Far1-mechanism (separate view):
|
|
|
![](/pics/ycm_cell_cycle_scheme_20140122_Far1.png)
|
|
|
![](pics/ycm_cell_cycle_scheme_20140122_Far1.png)
|
|
|
* We included two types of phosphorylations on Far1 that play a role in the mechanism:
|
|
|
* T306: Stabilizing phosphorylation by Fus3
|
|
|
* S86: Phosphorylation mediated by Cln2 leading to destruction of Far1
|
|
|
|
|
|
The updated version of the Network including the new Far1-mechanism (see above) looks as follows:
|
|
|
![](/pics/ycm_cell_cycle_scheme_20140124.png)
|
|
|
![](pics/ycm_cell_cycle_scheme_20140124.png)
|
|
|
|
|
|
#### Issues
|
|
|
* Sic1 level deceases while cell is arrested
|
... | ... | @@ -115,7 +115,7 @@ The updated version of the Network including the new Far1-mechanism (see above) |
|
|
* For consistency, all species are now produced as well as degraded.
|
|
|
* CDC module was split into a regulating module and the GEX_TRX/TRL modules to represent the different functions.
|
|
|
* The current model structure looks like this:
|
|
|
![](/pics/ycm_cell_cycle_scheme_20170925.png)
|
|
|
![](pics/ycm_cell_cycle_scheme_20170925.png)
|
|
|
|
|
|
## Other Cell Cycle Models
|
|
|
**Barik et al. (2010) [20739927](http://www.ncbi.nlm.nih.gov/pubmed/20739927):**
|
... | ... | |